Pure and Organic CBD & and Hemp Products

Effective medicine provided by mother nature

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Why CBD?

More and more renowned scientists worldwide publish their researches on the favorable impact of CBD on the human body. Not only does this natural compound deal with physical symptoms, but also it helps with emotional disorders. Distinctly positive results with no side effects make CBD products nothing but a phenomenal success.

This organic product helps cope with:

  • Tight muscles
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Range of Products

We have created a range of products so you can pick the most convenient ones depending on your needs and likes.

CBD Capsules Morning/Day/Night:

CBD Capsules

These capsules increase the energy level as you fight stress and sleep disorder. Only 1-2 capsules every day with your supplements will help you address fatigue and anxiety and improve your overall state of health.

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CBD Tincture

CBD Tincture

No more muscle tension, joints inflammation and backache with this easy-to-use dropper. Combined with coconut oil, CBD Tincture purifies the body and relieves pain. And the bottle is of such a convenient size that you can always take it with you.

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Pure CBD Freeze

Pure CBD Freeze

Even the most excruciating pain can be dealt with the help of this effective natural CBD-freeze. Once applied on the skin, this product will localize the pain without ever getting into the bloodstream.

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Pure CBD Lotion

Pure CBD Lotion

This lotion offers you multiple advantages. First, it moisturizes the skin to make elastic. And second, it takes care of the inflammation and pain. Coconut oil and Shia butter is extremely beneficial for the health and beauty of your skin.

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Making the Distinction

THC CBD anxiety, PTSD? for vs depression,

petux21
24.06.2018

Content:

  • THC CBD anxiety, PTSD? for vs depression,
  • CBD Gummies for Anxiety and Depression
  • How Does CBD Work?
  • Cannabidiol (CBD) combined with some THC has been shown to be effective for depression and a variety of related anxiety disorders like PTSD, SAD, GAD. Notably, PTSD and OCD are no longer classified as anxiety disorders in the recent Cannabidiol (CBD) is a phytocannabinoid constituent of Cannabis sativa that “post-traumatic stress disorder” or “panic disorder” or “obsessive compulsive. CBD constitutes about 40% of the active LTP and depression) in several brain areas.

    THC CBD anxiety, PTSD? for vs depression,

    Not only is it able to treat a wide range of ailments ranging from cancer to arthritis, CBD is known to be effective without causing any obvious side effects. It can be used safely in the long-term without causing addiction and dependence. These products provide patients with a tasty and fun way to medicate themselves. CBD, also known as cannabidiol, is one of the main cannabinoids found in the cannabis and hemp plants. CBD is known to treat a number of illnesses, both mental and physical.

    Some of the things that CBD is most commonly used to treat include: These are just a few of the things that CBD can be useful for treating. CBD is attractive to a number of people because it presents a holistic alternative to a lot of pharmaceutical medications. Many people find that their pharmaceuticals may be effective for treating a problem on the surface, but the side effects often compete with the benefits and in the long-run the illness is rarely treated.

    CBD gummies, on the other hand, can help people manage the symptoms of their illnesses without actually becoming dependent on a drug or overwhelmed by side effects. This provides a unique opportunity to actually heal the root of the problem. THC, or tetrahydrocannabinol, is another cannabinoid. This one is largely responsible for many of the psychoactive effects that a person can experience when smoking marijuana. Their molecules have the same number and same type of atoms; they are simply arranged differently.

    This contributes to the vast differences in experiences when using these two compounds. The interesting thing about CBD is that it will not have many effects if you are not treating an actual problem. That is to say, CBD works by helping to restore balance and function to the endocannabinoid system ECS , as mentioned earlier. Unfortunately, the reality is that most of us have at least some imbalance in our ECS.

    For these people, CBD is known for providing a number of positive benefits: All of these benefits can work together to help ward off various illnesses and diseases. CBD does not get you high. However, because of the arrangement of these molecules, the two compounds act entirely different inside the body.

    There are a huge number of different products containing CBD available. The variety in products allows for patients to choose from a number of ways of consuming CBD. The different methods of taking CBD will provide differences in the effects and duration of the substance. This is because the oil provides you with a concentrated form of the active extract that can be consumed in a number of ways.

    The most effective way to use CBD oil is to take it sublingually. This involves holding the oil under your tongue for about 5 minutes so the CBD can be absorbed into the blood vessels there. One of the best things about edibles is that they are more slowly metabolized than the other forms of CBD. This means that the active effects may come on a bit slower but they will linger for much longer. Many people were baffled by the implications of this, particularly because THC is well-known for causing anxiety in many people.

    Folks were wondering how a cannabinoid — especially one so similar to THC — could be used for fighting anxiety. For now, the simple fact of the matter is that CBD helps to manage anxiety by relaxing the mind and body, as well as balancing out the endocannabinoid system. CBD has been shown to be useful for fighting all sorts of anxiety, ranging from generalized anxiety to panic disorder.

    Many have found success using a vape pen to help them manage acute panic attacks. Animal studies have shown that CBD can affect every stage of the process of aversive conditioning. In addition, exposure to traumatic stress is essential for the development of PTSD, and CBD is effective in reducing both the cardiovascular responses and anxiogenic effects caused by stress Resstel et al.

    For example, CBD lowered responses related to trauma when administered before the acquisition Levin et al. CBD also proved to be effective in reducing responses to aversive memories by blocking the process of reconsolidation Stern et al. However, the most promising alternative, suggested by exposure-based psychotherapies, may be through enhancement of the extinction process by CBD Bitencourt et al. Before discussing the facilitating effects of CBD on the extinction of aversive memories, it is necessary to highlight the role of the eCB system in this process.

    The process of extinguishing an aversive memory requires the participation of CB1 receptors, which was discovered in a classic study by Marsicano et al. The authors showed that blocking the action of CB1 receptors, either by pharmacological antagonism or genetic deletion, in previously conditioned mice resulted in strongly impaired short- and long-term extinction in fear-conditioning tests the function of CB1 receptors in the process of extinction of aversive memories is detailed in Wotjak, ; Lutz, This finding raised a new question: Would potentialization of the eCB system facilitate the extinction process?

    The answer was not surprising, and several studies were published showing that eCB system potentialization could in fact facilitate fear extinction in different behavioral tasks Chhatwal et al. Given that, according to Bisogno et al. The answer once again was affirmative, and since then studies have shown that CBD can facilitate the extinction of aversive memories not only in animals Bitencourt et al.

    However, it is important to note that some studies suggest that the reduced expression of fear caused by CBD may result mostly from blocked reconsolidation of an aversive memory than its increased extinction Stern et al. Regardless of which stage of aversive memory processing CBD affects, it appears that, at least in animals, this compound interferes with memory processing in a way that potentially mitigates damaging responses. In addition to the possibility of CBD affecting different processes involved in aversive memory, animal studies also show favorable effects of this compound in the control of other frequent manifestations of PTSD symptomatology, such as sleep disorders.

    Studies in rats indicate that CBD may contribute to an increase in sleep duration and depth, and a decrease in anxiety responses induced by sleep disturbance Monti, ; Hsiao et al. However, a thorough review of CBD and anxiety lies beyond the scope of this paper. The interested reader may want to see recent reviews by Blessing et al. Research has also been moving in this direction, as we will see in the next section.

    Confirming animal study results in humans is essential for the validation of any strategy that demands a pharmacological therapy. In a study published by Das et al.

    Using inhaled CBD at a dose of 32 mg , a study in a model of aversive conditioning showed that the compound caused a reduction in the skin conductance response as well as in the expectation levels for the CS during new exposure.

    Consistent with results of animal studies, these findings show that CBD may be a pharmacological complement to be used in exposure-based therapy. An important consideration in relation to this study is that CBD facilitated the extinction of aversive conditioning only when administered immediately after, and not before, the process.

    Therefore, understanding at which moment exposure-based therapy with CBD should start is one of several issues that still need to be resolved Das et al. A case report published in by Shannon and Opila-Lehman described a year-old child who developed PTSD after being sexually abused before the age of five. The child showed significant relief of the symptomatology using CBD oil. Before the CBD therapy, the child underwent standard pharmacological treatment for the condition, which produced short-lasting partial relief, as well as significant side effects.

    However, CBD oil given at a dose of 12—25 mg once a day appeared to relieve key symptoms, such as anxiety and sleep disturbance, while inducing minimal side effects. Although CBD is considered safe Bergamaschi et al. However, it is not possible to analyze the proportion of CBD and THC in the plant used by the patients in these studies.

    Recent studies also point to a link between Cannabis use, possibly as a form of self-medication, and the occurrence of trauma-related events both in adolescents Bujarski et al. The more severe the traumatic experience, the greater the plant consumption Kevorkian et al. These findings may reinforce the theory that the entourage effect may be more important to the therapeutic effects of the plant than any single compound used in isolation. To confirm this theory, more studies are required for a review of Cannabis use in people with traumatic experiences, see Zer-aviv et al.

    The mechanisms of CBD action in behavioral responses related to trauma are still unclear. Understanding the mechanisms underlying CBD action, for example on the expression of aversive memories, is important because a better understanding of this phenomenon may lead to the possibility of more effective interventions in traumatic memories in PTSD.

    Several mechanisms of action have been proposed to explain the pharmacology of CBD and, as we shall see, they are far from universally accepted. Based on this assumption and taking into account different studies showing that the activation of CB1 receptors decreases the expression of behaviors related to aversive memories in rats Chhatwal et al.

    A recent review by Hill et al. Furthermore, animal studies have confirmed the importance of the CB1 receptor in mediating the effects of CBD on behavioral responses related to potentially traumatic memories Bitencourt et al. However, other research has shown that the answer will not be that simple. In a systematic search of the extant literature for original articles on the molecular pharmacology of CBD, we found a study by Ibeas Bih et al.

    The authors show that CBD can act through 65 discrete, specific molecular targets, including 10 receptors, 32 enzymes, 10 ion channels, and 13 transporters. With regard to the possible modulation of the eCB system, a study published by Massi et al. Nevertheless, because FAAH activity appears to be increased by chronic restraint stress in animal models as well as by anxiety-like behaviors Hill et al. In any case, a great deal of caution is needed when interpreting in vitro assays and, especially, when extrapolating in vitro results to the in vivo effects of CBD.

    This mechanism may be the most promising possibility to explain at a molecular level the inhibitory effects of CBD on behavioral responses related to the recall of traumatic events and it is worth further investigation. However, controversy regarding the effects of CBD on serotonergic transmission remains. A study by Rock et al. In this study, the authors suggested that the 5HT 1A -mediated effects of CBD might involve allosteric interactions with the receptor binding site or interference with intracellular pathways Rock et al.

    The possible interaction of CBD with the serotonergic receptor, also observed in the eCB system, has not been confirmed in vivo Ibeas Bih et al. Another molecular target, still less explored, that may mediate, at least in part, the effects of CBD on the expression of aversive memories, is the adenosinergic system. It has now been established that the blocking of the eCB system leads to an increase in the expression of fear responses, whereas eCB system stimulation causes a decrease in such responses.

    Drawing parallels between eCB and adenosinergic signaling, adenosinergic receptor stimulation direct or indirect may represent an alternative treatment for trauma-related psychiatric disorders. Moreover, indirect stimulation of the adenosinergic system may explain the effects of CBD on aversive memories.

    Given the precariousness of the extrapolation of in vitro results to in vivo effects, the potential role of the adenosinergic system in the CBD-induced inhibition of aversive memory expression requires further investigation. We are still far from reaching a consensus regarding the possibility of other molecular targets mediating the effects of CBD on aversive memories. Precisely for this reason, great care must be taken when interpreting the existing literature as well as proposing new experiments.

    In addition to the behavioral changes induced by treatment with CBD, some of which possibly mediated by the CB1 receptor, studies have also shown that chronic CBD treatment may facilitate neurogenesis in the hippocampus, a structure well known for its important role in processing memories Wolf et al. Among the brain areas implicated in the effects of CBD, it is also important to highlight the amygdala, which is hyperactive in patients with PTSD and may be related to the severity of the symptoms Shin et al.

    CBD attenuated the level of blood oxygenation in the amygdalae of healthy subjects exposed to different levels of anxiety Fusar-Poli et al. Reduction in the hyperactivity of the amygdala may also explain, in part, the therapeutic effects of CBD against the symptoms caused by PTSD Passie et al. The activity of the mPFC, a brain structure that plays an important role in the effects of CBD on the regulation of aversive responses Lemos et al. Finally, CBD-induced reduction of trauma-related responses raises a wide spectrum of possibilities involving multiple pharmacological and neural circuit mechanisms.

    Understanding how these mechanisms work is just one more of the various challenges in the study of cannabinoids as potential treatment for neuropsychiatric disorders. Human and animal studies suggest that CBD may offer therapeutic benefits for disorders related to inappropriate responses to traumatic memories.

    The effects of CBD on the different stages of aversive memory processing make this compound a candidate pharmacological adjunct to psychological therapies for PTSD. CBD also shows an action profile with fewer side effects than the pharmacological therapy currently used to treat this type of disorder. In addition, even at high doses, CBD does not show the anxiogenic profile of compounds that directly activate eCB transmission.

    However, even in the face of evidence pointing to the modulation of the eCB system, more studies are needed to develop a better understanding of the neurobiological mechanisms involved in CBD responses.

    Although much remains to be discovered about the effects of CBD on PTSD symptoms many steps have already been taken in this direction, which may yield a formulation of CBD for the treatment of patients with trauma and stress-related disorders. The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

    The authors would like to thank Eduarda C. RB and RT are also grateful to Professor Elisaldo Carlini, pioneer of cannabinoid research in Brazil, for his invaluable contributions in this field of research. National Center for Biotechnology Information , U.

    Journal List Front Neurosci v. Published online Jul Author information Article notes Copyright and License information Disclaimer. This article was submitted to Neuropharmacology, a section of the journal Frontiers in Neuroscience. Received Dec 28; Accepted Jul 3. The use, distribution or reproduction in other forums is permitted, provided the original author s and the copyright owner s are credited and that the original publication in this journal is cited, in accordance with accepted academic practice.

    No use, distribution or reproduction is permitted which does not comply with these terms. Abstract Post-traumatic stress disorder PTSD is characterized by poor adaptation to a traumatic experience. Introduction Post-traumatic stress disorder PTSD is a chronic psychiatric condition that may develop after experiencing a potentially traumatic event. Open in a separate window.

    Cannabinoids and Trauma-Related Disorder Cannabis sativa contains over compounds called phytocannabinoids. Facilitated extinction of contextual fear memory Via CB 1 receptors Lemos et al.

    Decreased acquisition of contextual fear memory Not shown Stern et al. Blockade reconsolidation of contextual fear memory Not shown Gazarini et al. Blockade reconsolidation of contextual fear memory Not shown.

    Not shown Das et al. Not shown Shannon and Opila-Lehman, How Does It Work, Anyway? Conclusion and Future Perspectives Human and animal studies suggest that CBD may offer therapeutic benefits for disorders related to inappropriate responses to traumatic memories. Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

    Acknowledgments The authors would like to thank Eduarda C. Cannabinoids modulate hippocampal memory and plasticity. Structure of cannabidiol, a product isolated from the marihuana extract of Minnesota wild hemp. The endocannabinoid system and post traumatic stress disorder PTSD: From preclinical findings to innovative therapeutic approaches in clinical settings. Safety and side effects of cannabidiol, a Cannabis sativa constituent. Pharmacologic alternatives to antidepressants in posttraumatic stress disorder: Psychopharmacological strategies in the management of posttraumatic stress disorder PTSD: What have we learned?

    Molecular targets for cannabidiol and its synthetic analogues: Facilitation of contextual fear memory extinction and anti-anxiogenic effects of AM and cannabidiol in conditioned rats. Corticosteroid-endocannabinoid loop supports decrease of fear-conditioned response in rats. Cannabidiol as a potential treatment for anxiety disorders. Posttraumatic stress symptom severity predicts marijuana use coping motives among traumatic event-exposed marijuana users.

    A cognitive neuroscience account of posttraumatic stress disorder and its treatment. Marijuana use among traumatic event-exposed adolescents: Cannabidiol blocks long-lasting behavioral consequences of predator threat stress: Cannabidiol, neuroprotection and neuropsychiatric disorders. Involvement of 5HT1A receptors in the anxiolytic-like effects of cannabidiol injected into the dorsolateral periaqueductal gray of rats.

    Multiple mechanisms involved in the large-spectrum therapeutic potential of cannabidiol in psychiatric disorders. The anxiolytic effect of cannabidiol on chronically stressed mice depends on hippocampal neurogenesis: Inhibition of an equilibrative nucleoside transporter by cannabidiol: Endocannabinoid signaling and synaptic function. Effects of acute systemic administration of cannabidiol on sleep-wake cycle in rats.

    Enhancing cannabinoid neurotransmission augments the extinction of conditioned fear. Cannabis and endogenous cannabinoid systems. Posttraumatic stress disorder and cannabis use in a nationally representative sample. Cannabidiol enhances consolidation of explicit fear extinction in humans. A current overview of cannabinoids and glucocorticoids in facilitating extinction of aversive memories: Opposite action of hippocampal CB1 receptors in memory reconsolidation and extinction.

    Effects of cannabinoids and cannabinoid-enriched Cannabis extracts on TRP channels and endocannabinoid metabolic enzymes. Its general strategy of action, tools for its pharmacological manipulation and potential therapeutic exploitation. Infusion of cannabidiol into infralimbic cortex facilitates fear extinction via CB1 receptors. P2X7 purinergic receptors participate in the expression and extinction processes of contextual fear conditioning memory in mice.

    CBD Gummies for Anxiety and Depression

    To understand the effects and health benefits of CBD, cannabis oil, hemp oil, and From social anxiety and panic disorder to post-traumatic stress disorder. If you're using CBD gummies to treat your anxiety and depression then you'll want to Rest assured, CBD and THC have vastly different effects, and CBD is not anxiety associated with serious conditions like post-traumatic stress disorder. Learn about CBD, what it is, how it works, side effects, and how it could help you with CBD vs. THC. Most times, people interchange CBD for tetrahydrocannabinol as well as on social anxiety disorder and post-traumatic stress disorder.

    How Does CBD Work?



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