Effects of cannabinoids on testosterone and protein synthesis in rat testis Leydig than CBN = CBD = CBG greater than or equal delta 9-THC = delta 8-THC. CBD and testosterone are two intricately tied yet poorly understood topics when the impact CBD oil may have on your testosterone levels. For smaller dosages, THC tends to increase testosterone production quite dramatically. However, mice that were given larger doses showed a marked decline in.
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The wide range of benefits associated with cannabis have garnered interest for use in cancer therapy. Research suggests that cannabinoids, including CBD, may have anti-tumor effects. While this is not enough to define cannabis as a treatment for cancer, it does make it attractive as a complement to other therapies , for both reducing symptoms and possibly enhancing the effects of anticancer drugs.
Terpenes and the wide spectrum of other chemical compounds found in hemp flower-bud extracts provide potent anti-inflammatory and antioxidant properties. This is a common source of confusion. Many people see hemp oil on grocery store shelves and assume or wonder if it contains CBD and other cannabinoids.
The hemp oil you might see on grocery store shelves is made by cold pressing hemp seeds. While hemp oil is a healthful option for a salad dressing, it has no medicinal value by itself. Cannabinoids, including CBD in hemp and THC in marijuana, are most highly concentrated in the flower buds, not the seeds.
These chemical components of the plant must be extracted from the flower buds to be useful. For medicinal use, cannabinoids are extracted from hemp and concentrated into a thick oil that, when ingested, elevates blood levels of cannabinoids for a more sustained period of time. CBD oil from hemp contains CBD and other cannabinoids, along with terpenes and other chemical components. The most common method, chemical extraction uses alcohol or hexane as solvents.
The solvent is dried off, leaving the dense oil — and possibly harmful residual solvents — behind. A newer method, CO 2 extraction is done without using chemical solvents. Instead, it uses carbon dioxide to extract the full range of chemical components from the flower buds and then distill them into dense CBD oil. Also sometimes called thermal extraction, vapor distillation uses hot air to safely vaporize the full spectrum of chemical components at high concentration from the buds, and then the vapor is distilled into CBD oil.
This method also activates the cannabinoids by removing an extra carboxyl ring from their molecular chain a chemical reaction called decarboxylation , enabling them to interact directly with CB receptors for maximal medicinal value. I believe vapor distillation is the best method for obtaining the full range of activated chemical compounds from the cannabis plant.
This method preserves the terpenes, which are beneficial on their own, and also enhance the properties of CBD via the entourage effect. The upsides of lipid-based extraction are that the fat helps make the CBD more bioavailable easy to absorb , and there are no harsh solvents used.
Condensed CBD oil can be taken as a thick paste, but this is the least pleasant option. More commonly, the CBD oil is mixed with a carrier oil, such as hemp oil or coconut oil, to a specific concentration of CBD. The distinctive taste — which comes from the terpenes and not the cannabinoids — is often masked with chocolate, mint, or other flavorings.
It typically comes in a small bottle with a dropper to administer the oil mixture. The best way to take CBD oil mixed with a carrier oil to a specific concentration is to place a few drops or dropperfuls under your tongue for 15 seconds to access the sublingual gland.
There, the CBD is absorbed directly into the bloodstream called sublingual consumption or administration for the fastest acting effects. Another method is to take a few drops or dropperfuls orally, swish the liquid around in your mouth, and then swallow it. CBD oil mixed with a carrier oil can also be taken as soft-gel capsules to avoid any taste, but absorption is only through the intestinal tract. The average dose range is mg of CBD, one to three times per day, though much higher doses of mg sometimes required to control pain are equally well tolerated.
Some people will notice benefit at the lower end of the dose range, but most people will need mg to notice any effects. Because different products provide different concentrations of CBD, the packaging usually states how much CBD is in the entire bottle as opposed to the amount in a certain number of drops or dropperfuls, so measuring can be a little tricky.
A dropperful of the medium grade product mg of CBD per fluid ounce will deliver about 15 mg of CBD — a good starting dose. And a dropperful of a high concentration product mg CBD per fluid ounce will provide about 50 mg of CBD per dropperful.
CBD oil is also available as soft gel capsules. With these, the mg quantity of CBD should be designated per capsule. Because some of the chemical compounds in capsules are lost during digestion, you may find you need to take a little more to experience the benefits. As with any medicinal herb, start at a low dose and gradually build up to a higher dose as you get used to the effects of the substance.
Most people notice benefits almost immediately, but some experts suggest that full benefit does not occur until after a couple of weeks of consecutive use. CBD isolate which is CBD alone acts very differently in the body than a spectrum of hemp chemical components.
Here are some quick definitions:. The cannabis plant naturally generates cannabinoids, terpenes, and other chemical compounds to serve different functions in the plant.
These functions include regulatory properties, potent antioxidants, and protection from microbes and insects. Any creature that consumes the chemicals from the plant gains these same benefits. When you consume CBD oil, you gain the benefits of all those chemical substances in natural synergy. For that reason, you get full benefit at a dose range of mg. CBD isolate is limited to that single chemical messenger.
The synergy provided by the full spectrum of chemicals in CBD oil is lost. This is likely why clinical studies using purified CBD require very high doses, in the range of mg of CBD several times daily, to see a benefit. When CBD is formally legalized at the national level, prescription drugs providing high doses of purified CBD will become available several are already in the pipeline.
Reported side effects of hemp oil with CBD are generally mild and uncommon and can include tiredness, loose stools, and mild changes in appetite and weight either increased or decreased.
Both hemp oil with CBD hemp flower-bud extracts and purified CBD CBD isolate have been shown in both animal and human clinical trials to be remarkably safe and well tolerated. Prolonged use is not associated with an increased risk of side effects. In research studies , up to mg of purified CBD per day has been used to address various medical illnesses without reported harmful effects including changes in heart rate, blood pressure, temperature, oxygen and carbon dioxide levels, electrolyte balance, gastrointestinal function, psychomotor functions, or sleep cycles.
Prolonged use at high doses has not shown potential for abuse of CBD. In fact, a clinical study published in found that recreational polydrug users did not show abuse potential with use of CBD. Long-term studies have not evaluated potential changes in hormonal balance or long-term adverse changes in liver function, though prolonged use of CBD enhances metabolism of certain drugs. Stopping CBD oil suddenly has not been associated with withdrawal effects.
While the cost of CBD oil products is presently high, it will likely come down dramatically after CBD and hemp are legal by federal standards — but prices will still vary widely. Reputable companies selling CBD oil products will state the CBD concentration and extraction methods on the bottle or website.
Typically, the concentration is stated as milligrams mg of CBD per fluid ounce though some products standardize mg of CBD to milliliters ml. The benefit comes from the amount of CBD consumed, not the amount of oil.
To calculate the cost per milligram of CBD, simply divide the dollar amount of the product by the total milligrams of CBD in the bottle. As for extraction methods, remember that vapor distillation and CO2 extraction are preferred. Lipid-based extractions will likely fall in the middle price-wise. The highest quality cannabis is grown indoors , so quality standards can be controlled. Use of clean water and organic methods of farming that are free of pesticide use and unnatural fertilizers are, of course, preferred.
With outdoor-farmed cannabis, quality standards and potency are not as easily controlled. Taste can be a sign of value, too. Poor quality oils will have a very unpleasant chemical taste, and they can cause significant burning to mouth tissues. A good quality product should be smooth and not cause significant burning. Interestingly, the best quality products are associated with a distinct cannabis taste, indicating that the full spectrum of chemical components with trace levels of THC are present.
Even in high doses, CBD oil will not cause euphoria or impair coordination, balance, or motor functions. Use of CBD oil is associated with improved sense of well-being, but not an exaggerated feeling of well-being.
Use of CBD oil has never been associated with hallucinations or abnormal mental activity. Creams and salves for musculoskeletal discomfort generally contain very small amounts of CBD that are absorbed through the skin.
Many of these products do provide significant benefit, however, but the benefit is likely derived from other aspects of CBD — especially terpenes from cannabis and essential oils, thanks to their anti-inflammatory properties. Though CBD will likely become a highly promoted ingredient in beauty products, it is unclear whether the concentration of CBD present in these products will provide a benefit.
There is near zero potential of becoming habituated to hemp CBD products. It should be noted that recreational use of marijuana high THC, low CBD cannabis does result in dependence but different from narcotics or alcohol, and not as debilitating. Chronic use of THC may be associated with atrophy in certain areas of the brain and reduction of certain cognitive functions at this point, studies are not conclusive.
Interestingly, studies have shown that taking CBD oil regularly can restore areas of the brain that have become atrophied in marijuana abusers.
There have been no reports of anyone overdosing on cannabis. This sets even recreational use of cannabis widely apart from narcotics and alcohol, both of which can cause severe respiratory depression and death at excessive doses. Excessive doses of hemp, and more especially, marijuana, may make you very agitated and feel terrible, but there are no known deaths from cannabis overdose.
Many food and beverage companies are already taking advantage of the growing CBD trend and adding CBD to food and beverage products, though the practice is not approved by the FDA. Using CBD in defined doses for medicinal purposes is one thing, but putting it in food and beverages is something entirely different. Someone may wind up getting CBD from multiple products, and so their daily dose could vary significantly.
Taking a standardized dose of CBD oil daily as a recognized medicinal is a very different thing from taking uncontrolled doses of CBD isolate daily infused artificially into food and beverage products, and the long term risk may be very different — no one really knows for sure. Like most herbs, cannabis does have some antimicrobial and immune-boosting properties, but it is not as strong an antimicrobial as many other herbs. There are many better herbal choices for overcoming chronic Lyme disease and similar conditions related to chronic infections with stealth microbes such as fibromyalgia and chronic fatigue syndrome.
The bottom line is, CBD oil is a good option for controlling symptoms associated with Lyme disease, fibromyalgia, and other chronic illnesses, but it should be combined with other antimicrobial and immunomodulating herbs for optimal benefit. CBD oil is best used intermittently to treat symptoms of pain or anxiety, or used chronically only until symptoms gradually resolve, and then discontinued.
The story around CBD will continue to change and evolve once hemp is legalized and as the industry continues to grow and advance. Rawls is a physician who overcame Lyme disease through natural herbal therapy. You can learn more about Lyme disease in Dr. You can also learn about Dr. Bill Rawls practiced conventional medicine for 15 years. However, when Lyme disease and fibromyalgia disrupted his career at age 45, he was forced into the world of herbal and alternative medicine.
He has since restored his health—and has a passion to help others do the same. Everything You Need to Know. Why did humans start using cannabis? How are hemp and marijuana different? Just wait a second. Before you jump into the deep end of the pool and head to your physician to get your prescription for medical grade weed, the answer is no. No to that fact that we are not encouraging you to go out and actively start smoking and eating weed, but rather to consider taking advantage of an underappreciated compound found in the cannabis plant.
Introducing Cannabidiol, which we shall affectionately refer to as just CBD from here forward. Excited to take your performance to new highs? Yes, pun very intended. Weed, as we know it, is cannabis cultivated for high levels of its psychoactive constituent, known as tetrahydrocannabinol THC. Arguably, without the presence of this compound, the bioactive effects of weed changes altogether, from what we know it to be, to something that holds great promise to athletes. This is what CBD is. Possessing cannabis with high THC content is the topic for another discussion altogether, but just know it is illegal in many places.
However, CBD is not like his better known cousin. In fact, CBD was found in a study to interfere with the secretion of cortisol , reducing blood levels significantly. Though the study that found these results included only 11 subjects, even without the scientific verification, anecdotal evidence has revealed that people who use THC rich cannabis strains are known to supplement with CBD to reduce the effects of anxiety and increased adrenal function that occurs.
Are you hoping to build the body of a god on four hours sleep per night? CBD oil can help. It has a rather contradictory mechanism, as it is not a potent sedative, and should really even be classified as a stimulant. CBD in very low doses activated the same adenosine receptors as caffeine, blocking the action of its substrate and preventing sleep.
However, at moderate to high doses which is the dose normally consumed for therapeutic benefit , it holds good potential as a sleep promoting agent. CBD once again has shown itself to have the opposite effect of THC, suppressing appetite and lending itself for use as an anti-obesity agent.
Inflammation is ongoing every minute of the day. In a way, inflammation is what is responsible for shortening of our lifespan , being responsible to a large degree for many of the chronic diseases that are the most common causes of mortality. Which begs the question: But life-extending benefits aside, we are more interested in keeping our bodies working at peak efficiency, since our goal is to enhance athletic performance.
So how does CBD help us along the yellow brick road? For one, CBD can help relieve the inflammation that occurs in joints as a result of heavy weights or constant use wear and tear injuries.
Cannabinoids: The Best Kept Secret
Smoking weed regularly can impact your testosterone levels. And cannabis could wind up damaging your muscle gains and overall health too. On the one hand, CBD can help provide pain relief and lift your spirits. a slight dip in testosterone levels after a bit of time passes. of time after smoking, and then produces an opposite effect. New research is shedding light on how it can also impact men's testosterone levels. We're going to look at what the research says and talk.