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28. Dixie Botanicals

system The nausea endocannabinoid and



  • system The nausea endocannabinoid and
  • Regulation of nausea and vomiting by cannabinoids and the endocannabinoid system
  • Cannabinoid Therapy for Chemotherapy Induced Nausea and Vomiting (CINV)
  • The brain centres that elicit nausea are far less . of the endocannabinoid system in the. Regulation of nausea and vomiting by cannabinoids and the endocannabinoid system. Sharkey KA(1), Darmani NA(2), Parker LA(3). Research has found that the body's endocannabinoid system is responsible for regulating the presence and intensity of nausea.

    system The nausea endocannabinoid and

    A randomized trial of oral nabilone and prochlorperazine compared to intravenous metoclopramide and dexamethasone in the treatment of nausea and vomiting induced by chemotherapy regimens containing cisplatin or cisplatin analogues.

    Eur J Cancer Clin Oncol. Deltatetrahydrocannabinol differentially suppresses cisplatin-induced emesis and indices of motor function via cannabinoid CB 1 receptors in the least shrew. The role of endocannabinoids and arachidonic acid metabolites in emesis. Molecular, Pharmacological, Behavioral and Clinical Features. Behaviorally active doses of the CB1 receptor antagonist SR A increase brain serotonin and dopamine levels and turnover. Cisplatin increases brain 2-arachidonoylglycerol 2-AG and concomitantly reduces intestinal 2-AG and anandamide levels in the least shrew.

    Antiemetic and motor-depressive actions of CP55, Excitability of prefrontal cortical pyramidal neurons is modulated by activation of intracellular type-2 cannabinoid receptors. Cannabinoids suppress synaptic input to neurones of the rat dorsal motor nucleus of the vagus nerve. Arterioscler Thromb Vasc Biol. Why do cannabinoid receptors have more than one endogenous ligand?

    Brain monoglyceride lipase participating in endocannabinoid inactivation. Preliminary efficacy and safety of an oromucosal standardized cannabis extract in chemotherapy-induced nausea and vomiting.

    Br J Clin Pharmacol. Basic mechanisms of migraine and its acute treatment. A new perspective on N-acylethanolamines as neural signaling molecules. Amelioration of cancer chemotherapy-induced nausea and vomiting by deltatetrahydrocannabinol. Effects on anandamide and oleoylethanolamide deactivation. J Pharmacol Exp Ther. Ictus emeticus and the insular cortex. Granular insular cortex inactivation as a novel therapeutic strategy for nicotine addiction.

    Role of endogenous cannabinoids in synaptic signaling. Deltatetrahydrocannabinol as an antiemetic for patients receiving cancer chemotherapy. A comparison with prochlorperazine and a placebo. Curr Drug Abuse Rev. Loss of retrograde endocannabinoid signaling and reduced adult neurogenesis in diacylglycerol lipase knock-out mice. Isolation, structure, and partial synthesis of an active constituent of hashish. J Amer Chem Soc. Behavioral regulation of the milieu interne in man and rat.

    Antidepressant like activity and modulation of brain monominergic transmission by blockade of anandamide hydrolysis. The taste reactivity test. Mimetic responses to gustatory stimuli in neurologically normal rats. Psychopharmacological activity of the active constituents of hashish and some related cannabinoids.

    Segregation of two endocannabinoid-hydrolyzing enzymes into pre- and postsynaptic compartments in the rat hippocampus, cerebellum and amygdala. Regulation of endocannabinoid release by G proteins: Superiority of nabilone over prochlorperazine as an antiemetic in patients receiving cancer chemotherapy. New Engl J Med. Management of nausea and vomiting in cancer and cancer treatment. Jones and Bartlett Learning; Boston: Nausea and emesis remain significant problems of chemotherapy despite prophylaxis with 5-hydroxytryptamine-3 antiemetics: Wilmot cancer center community clinical oncology program study of cancer patients treated in the community.

    Serotonin and cholecystokinin activate different populations of rat mesenteric vagal afferents. Why is the neurobiology of nausea and vomiting so important? Differential effects on gastrointestinal and hepatic vagal afferent fibers in the rat by the anti-cancer agent cisplatin, Auton.

    A comparative behavioral, anatomical, and physiological study. Central neurocircuitry associated with emesis. International Union of Pharmacology. Classification of cannabinoid receptors. Staphylococcal enterotoxin induces emesis through increasing serotonin release in intestine and it is downregulated by cannabinoid receptor 1. The Science of Marijuana. Oxford University Press; Cannabinoids and the gut: The effect of leptin receptor deficiency and fasting on cannabinoid receptor 1 mRNA expression in the rat hypothalamus, brainstem and nodose ganglion.

    Somato-motor, autonomic and electrocorticographic responses to electrical stimulation of rhinencephalic and other structures in primates, cat, and dog; A study of responses from the limbic, subcallosal, orbito-insular, piriform and temporal cortex, hippocampus-fornix and amygdala. Fatty acid-binding proteins transport N-acylethanolamines to nuclear receptors and are targets of endocannabinoid transport inhibitors. Medicinal use of cannabis: Endocannabinoid-mediated control of synaptic transmission.

    Multiple functions of endocannabinoid signaling in the brain. Taste avoidance, but not aversion, learning in rats lacking gustatory cortex. Reduction in endocannabinoid tone is a homeostatic mechanism for specific inhibitory synapses.

    A one-year study to assess the safety and efficacy of the CB1R inverse agonist taranabant in overweight and obese patients with type 2 diabetes. Intravenous buspirone for the prevention of postoperative nausea and vomiting. Eur J Clin Pharmacol. A comparative analysis of the potential of cannabinoids and ondansetron to suppress cisplatin-induced emesis in the Suncus murinus house musk shrew Psychopharmacol Berl ; Attenuation of cyclophosphamide-induced taste aversions in mice by prochlorperazeine, delta 9-tetraydrocannabinol, nbilone and levonantradol.

    Dronabinol and prochlorperazine in combination for treatment of cancer chemotherapy-induced nausea and vomiting. J Pain Symptom Manag. Inactivation of N-acyl phosphatidylethanolamine phospholipase D reveals multiple mechanisms for the biosynthesis of endocannabinoids. Effect of manipulation of the endocannabinoid system on contextually-elicited conditioned gaping reactions in rats: A model of anticipatory nausea.

    Exposure to a lithium-paired context elicits gaping in rats: Exposure to a context previously associated with toxin LiCl - or motion-induced sickness elicits conditioned gaping in rats: Evidence in support of a model of anticipatory nausea.

    Deltatetrahydrocannabinol interferes with the establishment and the expression of conditioned rejection reactions produced by cyclophosphamide: The anti-nausea effects of CB1 agonists are mediated by an action at the visceral insular cortex. Inverse agonism of cannabinoid CB1 receptors potentiates LiCl-induced nausea in the conditioned gaping model in rats.

    Multiple pathways involved in the biosynthesis of anandamide. A biosynthetic pathway for anandamide. Pica--a model of nausea? Species differences in response to cisplatin. The metabolic serine hydrolases and their functions in mammalian physiology and disease.

    Distribution of cannabinoid receptors in the central and peripheral nervous system. Aversive effects of the synthetic cannabinoid CP 55, in rats. The cannabinoid CB1 antagonist AM produces food avoidance and behaviors associated with nausea but does not impair feeding efficiency in rats.

    An overview of some chemical and pharmacological aspects. Mechoulam R, Parker LA. The endocannabinoid system and the brain. Efficacy of dronabinol alone and in combination with ondansetron versus ondansetron alone for delayed chemotherapy-induced nausea and vomiting.

    Cur Med Res Opin. Central mechanisms of vomiting. The area postrema and vomiting. Emetic reflex arc revealed by expression of the immediate- early gene c-fos in the cat. DAG lipase involvement in depolarization-induced suppression of inhibition: Poison induced pica in rats. Localization of the CB1 cannabinoid receptor in the rat brain.

    Subacute to chronic mild traumatic brain injury. The brain circuitry underlying the temporal evolution of nausea in humans. The hidden island of addiction: Prolonged anandamide availability by anandamide transport inhibition attenuates nausea-induced behaviour in rats, and vomiting in shrews Suncus murinus Br J Pharmacol. CNS effects of CB2 cannabinoid receptors: Antiemetic effect of delta 9-tetrahydrocannabinol in chemotherapy-associated nausea and emesis as compared to placebo and compazine.

    Antiemetic effect of tetrahydrocannabinol. Compared with placebo and prochlorperazine in chemotherapy-associated nausea and emesis. Is lipid signaling through cannabinoid 2 receptors part of a protective system? Behavioral CRs elicited by a lithium- or an amphetamine-paired contextual test chamber. Tetrahydrocannabinol THC interferes with conditioned retching in Suncus murinus: An animal model of anticipatory nausea and vomiting ANV Neurorep.

    Deltatetrahydrocannabinol and cannabidiol, but not ondansetron, interfere with conditioned retching reactions elicited by a lithium-paired context in Suncus murinus: An animal model of anticipatory nausea and vomiting. Cannabinoid agonists attenuate and a cannabinoid antagonist potentiates lithium-induced conditioned rejection reactions in a rat model of nausea. Conditioned disgust, but not conditioned taste avoidance: A measure of conditioned nausea in rats.

    Can J Exp Psychol. Regulation of nausea and vomiting by cannabinoids. Cannabinoid1 receptor in the dorsal vagal complex modulates lower oesophageal sphincter relaxation in ferrets. Appetite sensations and nausea and vomiting in pregnancy: Quality of acquired responses to tastes by Rattus norvegicus depends on type of associated discomfort.

    Cannabinoid-induced reduction in antral pacemaker frequency: Emerging strategies for exploiting cannabinoid receptor agonists as medicines.

    International Union of Basic and Clinical Pharmacology. Cannabinoid receptors and their ligands: Effect of rimonabant, a cannabinoid-1 receptor blocker, on weight and cardiometabolic risk factors in overweight or obese patients: The molecular logic of endocannabinoid signalling. Addition of the neurokinin 1 receptor antagonist aprepitant to standard antiemetic therapy improves control of chemotherapy-induced nausea and vomiting.

    Results from a randomized, double-blind, placebo-controlled trial in Latin America. Prospective randomized double-blind trial of nabilone versus domperidone in the treatment of cytotoxic-induced emesis.

    Receptor-selective agonists induce emesis and Fos expression in the brain and enteric nervous system of the least shrew Cryptotis parva Pharmacol Biochem Behav. Cannabidiol, a non-psychotropic component of cannabis, attenuates vomiting and nausea-like behaviour via indirect agonism of 5-HT 1A somatodendritic autoreceptors in the dorsal raphe nucleus. Tetrahydrocannabinolic acid reduces nausea-induced conditioned gaping in rats and vomiting in Suncus murinus.

    The effect of cannabidiol and URB on conditioned gaping a model of nausea elicited by a lithium-paired context in the rat. Effect of low doses of cannabidiolic acid and ondansetron on LiCl-induced conditioned gaping a model of nausea-induced behaviour in rats. Suppression of lithium chloride-induced conditioned gaping a model of nausea-induced behaviour in rats using the taste reactivity test with metoclopramide is enhanced by cannabindiolic acid.

    Pharmacological mechanisms of 5-HT 3 and tachykinin NK 1 receptor antagonism to prevent chemotherapy-induced nausea and vomiting. The influence of ACEA--a selective cannabinoid CB1 receptor agonist on whole blood and platelet-poor plasma serotonin concentrations.

    Treatment of nausea and vomiting: Acta Physiol Oxf ; Characterization of cannabinoid-1 receptors in the locus coeruleus: Neuronal mechanisms and the treatment of motion sickness. Differential anxiogenic, aversive, and locomotor effects of THC in adolescent and adult rats. Psychopharmacol Berl ; Nausea and vomiting of pregnancy in an evolutionary perspective. Am J Obstet Gynecol. The novel cannabinoid CB1 receptor neutral antagonist AM suppresses food intake and food-reinforced behavior but does not induce signs of nausea in rats.

    Double-blind comparison of the antiemetic effects of nabilone and prochlorperazine on chemotherapy-induced emesis. Neuron- type specific cannabinoid-mediated G protein signalling in mouse hippocampus. Oxford University Press; Oxford: Inhibition of monoacylglycerol lipase attenuates vomiting in Suncus murinus and 2- arachidonoyl glycerol attenuates nausea in rats.

    Endocannabinoid system in the adult rat circumventricular areas: Cannabinoids for control of chemotherapy induced nausea and vomiting: Fatty acid amide hydrolase is located preferentially in large neurons in the rat central nervous system as revealed by immunohistochemistry.

    Double dissociation between regulation of conditioned disgust and taste avoidance by serotonin availability at the 5-HT3 receptor in the posterior and anterior insular cortex. Ondansetron interferes with unconditioned lying-on belly and acquisition of conditioned gaping induced by LiCl as models of nausea-induced behaviors in rats. Enzymological studies on the biosynthesis of N- acylethanolamines. Biosynthesis and degradation of the endocannabinoid 2-arachidonoylglycerol.

    The effects of two antiemetics on patients undergoing radiotherapy. Identification and functional characterization of brainstem cannabinoid CB2 receptors. Cannabinoids inhibit emesis through CB1 receptors in the brainstem of the ferret. Delta9-tetrahydrocannabinol selectively acts on CB1 receptors in specific regions of dorsal vagal complex to inhibit emesis in ferrets.

    WIN 55, prevents mechanical allodynia but not alterations in feeding behaviour induced by chronic cisplatin in the rat. The antiemetic interaction of Delta9-tetrahydrocannabinol when combined with tropisetron or dexamethasone in the least shrew. Dual fatty acid amide hydrolase and monoacylglycerol lipase blockade produces THC-like Morris water maze deficits in mice. This serotonin can then join itself to 5-HT3 receptors located in the peripheral and central nervous systems and is known to be one of the causes of nausea and vomiting.

    Classical management involves 5-HT3 receptor antagonists , which inhibit the binding itself. This form of antiemetic has proven to be very successful but it does not work for everyone and in some cases, can produce some adverse effects such as insomnia, nausea and dizziness. For that reason researchers have begun investigating cannabinoids. Both are artificially manufactured variations of tetrahydrocannabinol one of the active components that is naturally produced within the cannabis plant.

    These are usually given to the patient in case he has not responded to the conventional medication. Since this conclusion, more and more studies has been carried out to find out if the cannabinoids mechanisms or the endocannabinoid system may have any influence over the sickness.

    When a cannabinoid is administered into the human body, it binds to its receptor member of the endocannabinoid system , labelled as cannabinoid receptor 1 CB1 and cannabinoid receptor 2 CB2 , among others. These receptors are in the central nervous system, the immune system, the gastrointestinal tract and also within the emetic reflex pathway.

    Therefore, it is understood that cannabinoids operate by inhibiting the interaction between serotonin and its receptor.

    An article published with animal models vomiting was induced with CB1 receptor antagonist, cisplatin , revealed that THC was hugely effective in the reduction of emesis.

    These results mirrored those found in a similar study with humans. A case report by Soriano-Co and colleagues demonstrated that patients diagnosed with CHS were more likely to have frequent clinician visits, ED visits, and hospitalizations. There are multiple hypotheses regarding the pathophysiology of CHS; however, because of the multitude of active chemicals in cannabis and the existence of various sites of action, the definitive pathophysiological process is unknown.

    Additionally, not all cannabis users develop CHS, causing further difficulty in describing the syndrome. At low doses, THC is known to exert an antiemetic effect, but with heavy and chronic cannabis use, the opposite is seen. It has been suggested that THC accumulates over time because of its large volume of distribution.

    THC may directly activate CB 1 receptors in the enteric nervous system and reduce gastric motility, increasing the risk of nausea and vomiting with excessive activation. Chronic cannabis use is the main risk factor for the development of CHS. CHS has several phases, which have been classified as preemetic, hyperemetic, and recovery. Commonly, cannabis users increase their cannabis intake during the preemetic phase in an effort to alleviate nausea.

    This may lead to weight loss and acute dehydration, potentially resulting in prerenal failure. To alleviate symptoms, patients may start hot bathing—i. Hot bathing may help with thermoregulation and reduction of blood flow to the stomach by affecting peripheral vasodilation and redistribution from splanchnic circulation, resulting in decreased vomiting. Patients typically discontinue hot bathing when symptoms are not present and begin it again once nausea and vomiting recur after future cannabis use.

    Many patients seek medical care for their symptoms during the hyperemetic phase. As a result, patients may undergo extensive negative workups for various other conditions, such as CVS, pancreatitis, and gastroparesis, which may mimic some symptoms of CHS.

    Once the nausea and vomiting subside, usually within 48 hours, the patient enters the recovery phase. Recovery may range from days to months and is associated with cessation of cannabis use. If the patient reinitiates cannabis, symptoms usually return. Gregoire and colleagues described a patient with a history of bipolar mania and cannabis use who developed CHS. Reinitiation of lithium in the hospital triggered no additional vomiting, indicating that cannabis was the likely cause.

    Diagnostic criteria for CHS have been proposed. Long-term cannabis use is essential for diagnosis. The length of time it takes to develop CHS varies; however, most patients present 1 to 5 years after chronic cannabis use. Presentation with symptoms similar to those of CHS prior to 1 year of chronic cannabis use should not preclude diagnosis. Major features of CHS include severe cyclic nausea and vomiting, resolution of symptoms upon cannabis cessation, relief achieved by bathing in hot water, epigastric or periumbilical abdominal pain, and weekly cannabis use.

    Supportive care is indicated for all patients who present in the hyperemetic phase of CHS. If the patient can tolerate it, oral intake of fluids is recommended for hydration.

    Some patients cannot tolerate oral hydration owing to excessive vomiting, so IV fluids may be indicated for volume depletion associated with dehydration. Compulsive hot bathing is a hallmark learned behavior that patients may use to minimize symptoms associated with CHS.

    As was discussed previously, hot bathing may help with thermoregulation. Another theory is that peripheral vasodilation and redistribution from splanchnic circulation may reduce blood flow to the stomach, resulting in decreased vomiting.

    Antiemetics have been used without success to relieve symptoms of CHS.

    Regulation of nausea and vomiting by cannabinoids and the endocannabinoid system

    The endo- cannabinoid system (ECS) consists of the naturally occur- ring ligands cannabis is widely used for the treatment of nausea and abdominal pain. Motion sickness can be extremely stressful but the neurobiologic mechanisms The endocannabinoid system (ECS) represents an important. With the discovery of the endocannabinoid system, novel ways to regulate both nausea and vomiting have been discovered that involve the production of.

    Cannabinoid Therapy for Chemotherapy Induced Nausea and Vomiting (CINV)



    The endo- cannabinoid system (ECS) consists of the naturally occur- ring ligands cannabis is widely used for the treatment of nausea and abdominal pain.


    Motion sickness can be extremely stressful but the neurobiologic mechanisms The endocannabinoid system (ECS) represents an important.


    With the discovery of the endocannabinoid system, novel ways to regulate both nausea and vomiting have been discovered that involve the production of.


    PDF | BACKGROUND: A substantial number of individuals are at risk for the development of motion sickness induced nausea and vomiting.


    Further research needs to clarify how the endogenous cannabinoid system is involved in the experience of nausea, and more specifically, how.

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