DMD - Corticosteroid medicineIf your child has asthma or allergic rhinitis hay feveryour pediatrician may prescribe a corticosteroid, also commonly referred to as a steroid. These medicines are the best available to decrease the swelling and irritation inflammation that occurs with persistent asthma or allergy. They are not the same as the anabolic steroids that are used injecting testosterone steroids by some athletes to build muscles. The medicine works in 2 ways. Systemic corticosteroids must go through the body to treat the inflammation. Inhaled corticosteroid side effects children intranasal corticosteroids go directly to where corticosteroid side effects children inflammation is.
Minimizing side effects of systemic corticosteroids in children. - PubMed - NCBI
Sign up for Insight Alerts highlighting editor-chosen studies with the greatest impact on clinical care. Describe the mechanism of action, list indications for therapy, and discuss the adverse effects of corticosteroid therapy in children.
Delineate the mechanism of action and adverse effects of other immunosuppressive agents frequently used in children. Discuss the immunization recommendations for children receiving immunosuppressive therapy. Corticosteroids are the most potent, naturally occurring anti-inflammatory agents known.
Despite more than 50 years of controversy regarding their clinical use, risks, and benefits, corticosteroids still play a significant role in the management of a wide variety of diseases. They have reduced the morbidity and mortality significantly in children afflicted with leukemia, asthma, rheumatic diseases, and other inflammatory disorders. In this article, we review the mechanism of action, clinical indications, and adverse effects of corticosteroids and other commonly used immunosuppressive agents in children.
We also review immunization recommendations for children receiving immunosuppressive therapy. Corticosteroids have a diverse role in the human body at the physiologic level. The actions of glucocorticoids include: Glucocorticoids also have pharmacologic properties that are used in the treatment of rheumatic and other inflammatory diseases.
Cellular receptors for cortisol are ubiquitous in cell cytoplasm, reflecting the critical role of the hormone in maintaining cell homeostasis. The type 1 glucocorticoid receptor, known as the mineralocorticoid receptor, has high affinity for aldosterone. The type 2 glucocorticoid receptor, known as the glucocorticoid receptor, exhibits strong affinity for dexamethasone. Regain Access - You can regain access to a recent Pay per Article purchase if your access period has not yet expired.
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Search for this keyword. From the American Academy of Pediatrics. Abraham Gedalia , Avinash K. Objectives After completing this article, readers should be able to: Introduction Corticosteroids are the most potent, naturally occurring anti-inflammatory agents known.
Mechanism of Action of Corticosteroids Corticosteroids have a diverse role in the human body at the physiologic level.
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Subjects Pharmacology Therapeutics Pharmacology.