Hormone Therapy for Prostate CancerMen with hormpne cancer that is small and confined to the prostate gland but at risk of growing and spreading, do better if they are treated with radiotherapy combined with androgen deprivation therapy ADTwhich lowers their testosterone levels. Bolla explained that these trial results indicate that this combined treatment approach should be an option proposed for men with localized prostate cancer that has an intermediate or high risk of growing and spreading. Bolla and colleagues from 37 centers in 14 countries recruited men to a clinical trial. Exposure to non-steroidal anti-inflammatory drugs during pregnancy and risk of miscarriage hormone shots before radiation had early stage prostate tumors, as beflre by analyses of biopsy samples and levels of prostate specific antigen PSAthat were at intermediate or high risk of growing and hormone shots before radiation to other parts of the body. The patients were randomized to receive either radiotherapy alone or radiotherapy and two subcutaneous injections of luteinizing hormone-releasing hormone bffore LH-RH analogueswhich lower levels of testosterone to cause reversible chemical castration.
Hormonal Therapy for People with Prostate Cancer | Memorial Sloan Kettering Cancer Center
Find out about hormone treatment for prostate cancer, when you have it and possible side effects. Hormones occur naturally in your body.
They control the growth and activity of normal cells. Testosterone is a male hormone mainly made by the testicles. Prostate cancer depends on testosterone to grow. Hormone therapy blocks or lowers the amount of testosterone in the body.
This can lower the risk of an early prostate cancer coming back when you have it with other treatments. Or it can shrink an advanced prostate cancer or slow its growth.
You might have hormone therapy before, during and after radiotherapy. Doctors usually recommend that you have the treatment for between 3 months and 3 years. How long depends on the risk of your cancer coming back and how many side effects you get. You might have it with other treatments such as high frequency ultrasound treatment or internal radiotherapy. Your doctor might suggest you have intermittent therapy. This is when you have treatment for 6 to 12 months and then have a break for a few months.
You then start treatment again and have another break. With intermittent therapy, you may have fewer side effects. At present the evidence is that intermittent treatment is not worse than having hormone treatment all the time.
Talk to your doctor about this. Hormone therapy is also a treatment for cancers that have spread to another part of the body. You might have it with chemotherapy such as docetaxel.
The injections work by blocking messages from a gland in the brain that tell the testicles to produce testosterone.
At first, the injections may make your symptoms worse. This is called tumour flare. Your doctor will give you an anti androgen tablet to take for the first 4 to 6 weeks of your treatment with the LH blocker to stop the tumour flare. This is the other type of injection. There is currently only one type called degarelix Firmagon. When you first start treatment, you have 2 injections on the same day. Then you have one injection a month. There is no risk of tumour flare with this treatment.
These tablets stop testosterone from your testicles getting to the cancer cells. Examples of anti androgens include:.
Flutamide and bicalutamide are less likely to cause erection problems and other side effects than leuprorelin Prostap or goserelin Zoladex. But they are more likely to cause breast swelling and tenderness. Enzalutamide is a treatment for men who have already had other types of hormone therapy and chemotherapy with docetaxel Taxotere that is no longer working. The trade name for abiraterone is Zytiga.
It is a type of hormone therapy that blocks an enzyme called cytochrome p Without this enzyme, the testicles and other body tissue can't make testosterone. You might have abiraterone if you have advanced prostate cancer and have already had other types of hormone therapy and chemotherapy with docetaxel Taxotere that is no longer working. Drug treatment is the usual way to stop your body producing testosterone. You have drug treatment as tablets or injections.
You usually only have surgery to remove your testicles if you need your testosterone reduced urgently. For example if your cancer has spread to your bones and is pressing on your spinal cord, your doctors might want to reduce the amount of testosterone quickly.
Your doctors may also suggest surgery as an option if you don't want to have treatment with medicines. PSA is a protein made by both normal and cancerous prostate cells. It is in the blood in small amounts in all men, unless they have had their prostate gland completely removed. While the hormone therapy is working, the level of PSA should stay stable or may go down.
But if prostate cancer cells are starting to grow and develop, the level of PSA may go up. Then your doctor may need to change your treatment. They will discuss this with you. Side effects of hormone therapy are due to the low levels of testosterone in your body.
Some are common to all hormone therapies for prostate cancer. Some effects vary from drug to drug. About Cancer generously supported by Dangoor Education since Call freephone or email us. Skip to main content. Prostate cancer Treatment Hormone therapy. What it is Hormones occur naturally in your body. When you have it Hormone therapy with radiotherapy You have this if: Hormone therapy alone Hormone treatment is also a treatment if: You then start treatment again and have another break With intermittent therapy, you may have fewer side effects.
Advanced cancer Hormone therapy is also a treatment for cancers that have spread to another part of the body. Find out more about treatment for advanced cancer. Find out about surgery to remove your testicles. Find out more about the side effects for the different types of hormone drugs. Search our clinical trials database for all cancer trials and studies recruiting in the UK.